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4-Bromo-2,5-dimethoxyphenethylamine (also known as Nexus, Bromo Mescaline, BDMPEA, Venus, and 2C-B) is a novel psychedelic substance of the phenethylamine class. It is perhaps the most well-known member of the 2C-x family, which are structurally related to the classical psychedelic mescaline. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism of action is not known.

2C-B was discovered in 1974 by the American chemist Alexander Shulgin, who was investigating psychedelic phenethylamines derived from mescaline.
In the 1970s, it first saw use as a therapeutic aid by a small circle of American psychotherapists and was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.

Recreational use was observed shortly afterward and it was briefly manufactured and sold commercially under such names as "Erox" and "Nexus" in "head" / "smart" shops and adult video stores before being federally scheduled in 1995.

Subjective effects include open and closed-eye visuals, time distortion, euphoria, and ego loss. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to mescaline, it is described as possessing a less serious or grandiose headspace than tryptamines like LSD or psilocybin mushrooms, placing greater emphasis on the visual and tactile domain.

Smaller doses (under 15 mg) are reported to be useful as a sensory and aesthetic enhancer (in a manner somewhat similar to MDMA) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect.

While more research is needed, it is generally thought to be physiologically well-tolerated, with a safety profile similar to classical psychedelics, which are known to have low abuse potential and toxicity.


Dosage
Threshold
5 mg
Light
10 - 15 mg
Common
15 - 25 mg
Strong
25 - 45 mg
Heavy
45 mg +
Duration
Total
5 - 8 hours
Onset
20 - 40 minutes
Come up
40 - 60 minutes
Peak
2 - 3 hours
Offset
1.5 - 3 hours
After effects
2 - 4 hours